强直性脊柱炎的发病与下列哪个遗传基因密切相关A．HLA—DR4B．HLA一B7C．HLA—B5D．HLA一B27E．HLA—DR3

强直性脊柱炎的发病与下列哪个遗传基因密切相关

A．HLA—DR4

B．HLA一B7

C．HLA—B5

D．HLA一B27

E．HLA—DR3

请帮忙给出正确答案和分析，谢谢！